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. Author manuscript; available in PMC: 2016 Sep 10.
Published in final edited form as: Oncogene. 2015 Jun 1;35(10):1250–1260. doi: 10.1038/onc.2015.179

Figure 6.

Figure 6

Expression of SREBP targets is associated with mTORC1 activation in human breast cancer. (a) Comparison of SREBP target gene expression and P-S6 levels in data from primary breast cancer samples. Expression of FASN, SCD, LDLR, and MVK in breast carcinoma samples from the TCGA, grouped by high (n=112) or low (n=116) P-S6-S240/244 levels. Data are shown as mean ± s.e.m. relative to low P-S6 samples. (b,c) Association of FASN and SCD protein levels with P-S6 levels in primary human breast cancers. Dot blots of six different matched pairs of breast cancer and normal tissue are shown, each spotted in triplicate (b). The log2 fold change of P-S6 levels in paired tumor versus normal tissue is graphed with log2 fold change of either FASN (n=40) or SCD (n=37) (c), with the coefficient of determination (R2) provided. (d) The data from c was grouped into high and low fold changes of P-S6 levels in tumor versus normal tissue and graphed for the fold-change in FASN and SCD protein levels.