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. Author manuscript; available in PMC: 2016 Sep 10.
Published in final edited form as: Oncogene. 2015 Jun 1;35(10):1250–1260. doi: 10.1038/onc.2015.179

Table 1.

Breast cancer cell lines used in this study with known mutations upstream of mTORC1.

Cell Line Mutations Subtypea
MDA-MB-468 PTEN p.V85_splice Basal
HCC1937 PTEN del/del Basal
MCF-7 PIK3CA E545K Luminal
BT-483 PIK3CA E542K Luminal
T-47D PIK3CA H1047R Luminal
MDA-MB-453 PIK3CA H1047R (PTENb) Luminal
Hs578T HRAS G12D Basal
MDA-MB-134-VI KRAS G12R Luminal
a

Subtype is based on the gene expression signature published by Neve et al.6

b

PTEN mutation with undefined effect.