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. 2015 Dec 2;35(48):15955–15970. doi: 10.1523/JNEUROSCI.3382-15.2015

Figure 1.

Figure 1.

The inhibitory and independent modulatory actions of SRIF and the DA D1 receptor agonist SKF38393 on intrinsic melanopsin-based light response in M1 ipRGCs revealed by the selective sst4 agonist L-803,087 and the D1 receptor antagonist SCH23390. Representative traces of a paired M1 ipRGCs light response in control (synaptic blocking mixture; black) or SKF38393 (5 μm) (A), SRIF (100 nm (B), L-803,087 (1 μm) (C), SRIF (100 nm) and SKF38393 (5 μm) (D), L-803,087 (1 μm) and SKF38393 (5 μm) (E), SCH23390 (5 μm) (F), or both SCH23390 (5 μm) and L-803,087 (1 μm) (G). Bottom panels in A–G show the average photocurrent amplitudes and significance of photocurrent reduction in the presence drug(s) represented with * (*p < 0.05). Recordings from intact OPN–EGFP flat-mount retinas.