Figure 8.

The selective sst₄ agonist L-803,087 modulated K⁺ and Ca²⁺ channel currents in M1 ipRGCs from OPN4–EGFP retinas. A, Outward I_K recording from an M1 ipRGC in a retinal slice in the absence (left) and presence (right) of L-803,087 (1 μm). B, Mean I–V relationships for I_K from recordings in slices in the absence (black) and presence (red) of L-803,087. C, I_Ca recording in an isolated OPN4–EGFP cell in the absence (left) and presence (right) of L-803,087. D, Mean I–V relationships for I_Ca pooled from slices and isolated cells in the absence (black) and presence (red) of L-803,087. Recordings were made in the presence of TTX (500 nm). Voltage command protocol is seen below the current trace. n = 4–5 cells per group. *p < 0.05.