Fig. 10.
Histamine and nitric oxide are not responsible for contractile synchronization with flow. Vessels treated with 100 μM NG-nitro-l-arginine methyl ester (l-NAME), 10 μM HDC incubated overnight to block histamine, both l-NAME (100 μM) and histidine decarboxylase (HDC; 10 μM), and 30 μM 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to block downstream effects of nitric oxide via the soluble guanylyl cyclase (sGC) pathway, all exhibited synchronization to the applied WSS waveform. *P < 0.05; ***P < 0.001; ****P < 0.0001.