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Cerebrovascular response to severe hypoxic (PaO2 = 36.1 ± 6.3 mmHg) and mild hypercapnic (PaCO2 = 45.9 ± 3.3 mmHg) breathing with placebo vs. dopamine. *Significantly different from placebo. Although the MCAv and PCAv response to hypoxia is reduced with dopamine, this is confounded by an increased compliance of the cerebral vascular bed (middle). Therefore, true cerebral volumetric flow (ICA and VA) response to hypoxia is largely unaltered with dopamine.
