Signaling pathways of silent mating-type information regulation (Sirt) 1 in the heart. Sirt1 can modulate fatty acid oxidation, cardiac hypertrophy, apoptosis, oxidative stress, and autophagy through deacetylation of NF-κB, Akt, Forkhead box class O (FoxO), and p53. PPAR-α, peroxisome proliferator-activated receptor-α; Trx1, thioredoxin-1; Bcl-xL, B-cell lymphoma-extra large.