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. 2015 Sep 25;309(10):H1655–H1666. doi: 10.1152/ajpheart.00408.2015

Fig. 2.

Fig. 2.

Effect of fluid shear stress (FSS) exposure on placental growth factor (PLGF) protein expression in cocultures and arterioles. A: cocultures were exposed to static control conditions (no FSS), normal FSS (0.07 Pa), or high FSS (1.24 Pa). PLGF protein in medium was assessed prior to and up to 24 h after shear exposure. A: neither waveform had a significant effect on PLGF protein levels after 1 h of exposure (n = 5). B: 2 h of exposure to high, but not normal, FSS induced a significant increase in PLGF protein compared with static control (n = 5). *P < 0.001. C: mesenteric arterioles (∼150 μm ID) were cannulated and perfused with 1% BSA-PSS for 2 h. Perfusion with a pressure gradient of 50 mmHg significantly increased PLGF mRNA compared with perfusion with a pressure gradient of 20 mmHg (n = 5). *P < 0.05.