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Role of nitric oxide (NO) in the FSS-induced increase in PLGF protein. A: high, but not normal, FSS significantly increased nitrate/nitrite levels immediately after shear exposure compared with static control (n = 5). *P < 0.01. B: the NO synthase inhibitor NG-nitro-l-arginine methyl ester (l-NAME, 100 μM) had no effect on the shear-induced increase in PLGF protein (n = 5). *P < 0.05.
