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High-dose leptin-induced cardiac arrhythmias. A: leptin at 50 μg/kg induced premature ventricular beats (arrows). B: in the presence of propranolol (30 mg/kg), leptin at 150 μg/kg triggered sinus pauses (bottom). Arrows indicate the time point when leptin was administrated. C: in the presence of propranolol (30 mg/kg), leptin at 300 μg/kg induced ventricular tachycardia. All experiments were repeated in 3–4 rats. Prop, propranolol.
