Table 1.

NAC improves morphology and diastolic function in hypertrophic cardiomyopathy as assessed by echocardiography

Parameter (Sample Size)	NTg (n = 6)	NTg NAC (n = 9)	Tm-E180G (n = 6)	Tm-E180G NAC (n = 9)
Males/females (n)	3/3	3/6	3/3	5/4
Body weight, g	23.0 ± 1.73	21.7 ± 0.60	25.1 ± 1.57	21.8 ± 0.95
Heart rate, beats/min	500 ± 31	473 ± 15	428 ± 8	542 ± 21§
LA size, mm	1.26 ± 0.06	1.36 ± 0.08	2.19 ± 0.10**,††	1.58 ± 0.06*§
LV mass, mg	43.90 ± 5.27	49.17 ± 5.27	65.69 ± 5.21*†	51.39 ± 3.95
LVID;d, mm	3.73 ± 0.09	3.69 ± 0.11	3.75 ± 0.14	3.47 ± 0.10
LVID;s, mm	2.28 ± 0.09	2.46 ± 0.10	2.26 ± 0.08	2.19 ± 0.10
Relative wall thickness, mm	0.34 ± 0.03	0.29 ± 0.03	0.37 ± 0.03	0.38 ± 0.04
Ejection fraction, %	69.95 ± 1.44	63.77 ± 2.61	70.98 ± 0.56	71.01 ± 1.47
Fractional shortening, %	38.89 ± 1.22	34.33 ± 1.94	39.65 ± 0.45	39.72 ± 1.18
E-wave, mm/s	774 ± 34	779 ± 38	831 ± 81	846 ± 47
A-wave, mm/s	516 ± 32	490 ± 26	308 ± 64*†	540 ± 35§§
Em-wave, mm/s	26.23 ± 2.77	26.74 ± 2.24	20.34 ± 1.15*†	35.85 ± 4.50*†§
E/A ratio	1.54 ± 0.14	1.63 ± 0.09	3.03 ± 0.32**,††	1.64 ± 0.15§
E/Em ratio	30.94 ± 3.10	30.40 ± 2.20	41.44 ± 2.49*†	28.05 ± 3.30§

Values are means ± SE.

NAC, N-acetylcysteine; NTg, nontransgenic; Tm; tropomyosin; LA, left atrium; LV, left ventricular; LVID;d, LV internal dimension at diastole; LVID;s, LV internal dimension at systole.

^*P < 0.05 and

^**P < 0.001 vs. NTG;

^§P < 0.05 and

^§§P < 0.0001 vs. Tm-E180G;

^†P < 0.01 and

^††P < 0.001 vs. NTg NAC.