Figure 9. Decreased function of dysferlin‐deficient mouse hearts was independent of afterload .
Ex vivo working heart studies showed that when afterload was altered between 55 and 90 mmHg, contractile (A) and relaxation (B) velocities and maximum left ventricular pressure (LVPmax) (C) increased, whereas the stroke volume showed a trend of decrease (D). Similar responses to the change in afterload were seen for dysferlin knockout and wild‐type mouse hearts. The stroke volume of dysferlin knockout mouse hearts was lower than wild‐type controls at all afterload levels studied (D, *P<0.05 in two‐way ANOVA).