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. 2015 Nov 2;593(23):5127–5144. doi: 10.1113/JP271225

Figure 10. Decreased function of dysferlin‐deficient mouse hearts was independent of preload with preserved Frank‐Starling response .

Figure 10

Ex vivo working heart study showed that when preload was altered between 5 and 20 mmHg, the stroke volume of dysferlin knockout mouse hearts was lower than that of wild‐type hearts at all preload levels examined (*P<0.05 in Student's t‐test and # P<0.05 in two‐way ANOVA). However, dysferlin knockout and wild‐type groups exhibited parallel Frank–Starling responses to increases in preload (& P<0.05 when stroke volumes were compared with that at preload of 5 mmHg in two‐way ANOVA).