Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed model for the upregulation of HDAC1 in macrophages infected with MTB. PKA phosphorylates CREB leading to the transcriptional activation of c-Jun gene. c-Jun is recruited onto the HDAC1 promoter of macrophages infected with live, virulent MTB. HDAC1 is recruited to the promoters of proinflamatory genes resulting in transcriptional repression.
