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. 2015 Dec 2;5:90. doi: 10.3389/fcimb.2015.00090

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Copyright © 2015 Chandran, Antony, Jose, Mundayoor, Natarajan and Kumar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression of HDAC1 upon MTB infection. (A) Immuno-cytochemical imaging shows expression of HDAC1 in variously infected macrophages at 12 h; (B) 24 h post infection (PI); (C) at 12 h PI, levels of HDAC1 are low in MTB-infected macrophage cells; (D) at 24 h PI, levels of HDAC1 are high in MTB-infected macrophages; (E) levels of HDAC1 expression depend on the bacterial load inside the macrophages at 24 h PI; (F–H) densitometric analysis of HDAC1 bands normalized with that of histone H3. Quantitative data of HDAC1 protein is expressed as the mean of ratio of densitometric values of HDAC1 to histone H3 bands ± SD for three independent experiments. **p < 0.05.