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. 2015 Dec 2;5:90. doi: 10.3389/fcimb.2015.00090

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Copyright © 2015 Chandran, Antony, Jose, Mundayoor, Natarajan and Kumar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HDAC1 downregulates the IL-12B expression in macrophages 24 h post-MTB infection. (A) Status of HDAC1 and H3-Ac on the IL12B promoter by ChIP; (B) qPCR of IL-12B; (C) ELISA of IL-12p40. (D) IL-12 expression is upregulated in MTB-infected macrophages upon HDAC inhibition; (E) IL-12 expression is upregulated in MTB-infected macrophages when HDAC1 is knocked down. One of three independent experiments is shown for (A); for (B–E) data are the mean ± SD of three independent experiments. ^**p < 0.05.