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Effect of topical OTH on ear edema induced by single application of croton oil (OC) in Swiss mice. Animals were pretreated with saline in acetone, dexamethasone, OTH (pure, 100, 200, or 400 mg/ear). ANOVA followed by Student-Newman-Keuls test: ∗ p < 0.05 and ∗∗∗ p < 0.001 compared to negative control.
