Table 3.
Study | Schirmer test under anesthesia | Schirmer test result (mm) before beginning the study | Schirmer test result (mm) after treatment | Calculated difference (mm) between values before beginning the study and after treatment | HRT effect | |||
---|---|---|---|---|---|---|---|---|
HRT group | Control group | HRT group | Control group | HRT group | Control group | |||
Erdem et al., 2007 [14] | Yes | 3.9 ± 1.1 | 4.1 ± 0.8 | 3.2 ± 0.9 | 4.1 ± 0.9 | −0.7 ± 1.01 | 0 ± 0.85 | Negative |
| ||||||||
Affinito et al., 2003a [7] | Yes | 3.3 ± 1.5 | 3.2 ± 1.4 | 5.1 ± 1.3 | 3.4 ± 1.2 | 1.8 ± 1.41 | 0.2 ± 1.31 | Positive |
| ||||||||
Guaschino et al., 2003 [6] | No | 19.6 ± 8.1 | 17.8 ± 7.8 | 25.7 ± 7.9 | 17.4 ± 8.8 | 6.1 ± 8 | −0.4 ± 8.35 | Positive |
| ||||||||
Affinito et al., 2003b [7] | No | 13.4 ± 2.1 | 13.5 ± 2.7 | 17.8 ± 2.4 | 14.0 ± 2.8 | 4.4 ± 2.26 | 0.5 ± 2.75 | Positive |
| ||||||||
Taner et al., 2004 [15] | Not mentioned, but considered no | 11.7 ± 0.9 | 12.8 ± 1.0 | 11.68 ± 1.0 | 12.7 ± 1.0 | −0.02 ± 0.95 | −0.1 ± 1 | Negative |
| ||||||||
Scuderi et al., 2012a [13] | Not mentioned, but considered no | 1.45 ± 1.32 | 1.36 ± 1.31 | 5.63 ± 3.16 | 1.45 ± 1.09 | 4.18 ± 2.75 | 0.09 ± 1.22 | Positive |
| ||||||||
Scuderi et al., 2012b [13] | Not mentioned, but considered no | 1.09 ± 1.18 | 2.00 ± 1.22 | 6.36 ± 2.84 | 1.18 ± 1.04 | 5.27 ± 2.47 | −0.82 ± 1.14 | Positive |
HRT: hormone replacement therapy. Affinito 2003a and Affinito 2003b are the same study. The data for Schirmer tests with and without anesthetics were extracted and marked as Affinito 2003a and Affinito 2003b, respectively. Scuderi 2012a and Scuderi 2012b are the same study. The data for Schirmer tests from original grouping and reversed grouping are extracted and marked as Scuderi 2012a and Scuderi 2012b, respectively.