Figure 5.

Expression of Kv7.2 in the DRG and neuromas from mice treated with VLB during neuroma development. (A–H) Show images of representative ganglia stained with Kv7.2 and counterstained with NeuroTrace from each experimental condition as labeled. Kv7.2 labelled neurons decrease within the DRG 5 days after axotomy. VLB administration before and during neuroma development prevents the reduction of Kv7.2 labeled neurons. (I) Shows a 5 day neuroma in which Kv7.2 accumulations are evident. (K–M) are a magnification of (I) to show that Kv7.2 structures are co-labeled with NeuroTrace. (J) Show a 5 day neuroma from an animal treated with VLB before and during neuroma formation. Note that Kv7.2(+) structures are virtually absent. Scale bar in (A) applies to (B–J) images. Scale bar in (K) applies to (L,M) images.