Table 2.
Summary of Genome-Wide Significant Association Results
|
Study Design: Serostatus |
Study Design: IgG Levels |
||||
|---|---|---|---|---|---|
| Influenza A | JCPyV | MCPyV | EBV | ||
| SNP | ID (coded allele) | rs140012631 (C) | rs9269910 (A) | rs9269268 (C) | rs6927022 (A) |
| p value | 1.06 × 10−14 | 8.88 × 10−12 | 2.67 × 10−10 | 7.35 × 10−26 | |
| OR or betaa (95% CI) | 2.02 (1.84,2.19) | 1.74 (1.58,1.90) | 1.53 (1.40,1.66) | 0.16 (0.13,0.19) | |
| Classical HLA allele | Allele | HLA-DQB1∗05:01 | HLA-DQA1∗01:02 | HLA-DQB1∗06:02 | HLA-DRB1∗07:01 |
| p value | 4.91 × 10−12 | 4.11 × 10−9 | 1.35 × 10−9 | 1.01 × 10−14 | |
| OR or betaa (95% CI) | 0.53 (0.44,0.63) | 0.65 (0.56,0.75) | 0.56 (0.46,0.67) | −0.17 (−0.21,−0.12) | |
| Amino acid | Protein (position) | HLA-DRβ1 (96) | HLA-DRβ1 (133) | HLA-DRβ1 (13) | HLA-DRβ1 (11) |
| Omnibus p value | 2.64 × 10−16 | 1.27 × 10−11 | 1.87 × 10−10 | 5.85 × 10−23 | |
The strongest associated GWAS SNP, classical HLA allele, and amino acid position for each genome-wide significant virus is shown, along with corresponding p values and effect estimates. OR, odds ratio; CI, confidence interval.
a
OR is shown for the serostatus study design, and beta is shown for the IgG levels study design.