Table 1.
Clinical Characteristics of 756 Subjects in the Penn Heart Failure Study According to ProBNP1-108 Tertile
| Entire Cohort (n=756) | Tertile 1 (5–107 pg/ml) (n=252) | Tertile 2 (108–572 pg/ml) (n=252) | Tertile 3 (>572 pg/ml) (n=252) | p value* | |
|---|---|---|---|---|---|
| Mean age, yrs (s.d.) | 57 (14) | 51 (13) | 58 (14) | 60 (14) | <0.001 |
| Male, n (%) | 522 (69) | 161 (64) | 176 (70) | 185 (73) | 0.07 |
| Race | |||||
| Caucasian, n (%) | 617 (82) | 206 (82) | 204 (82) | 207 (83) | 0.97 |
| African American | 105 (14) | 35 (14) | 34 (14) | 36 (14) | |
| Other | 28 (4) | 9 (4) | 11 (4) | 8 (3) | |
| Tobacco Use | |||||
| Never, n (%) | 279 (37) | 108 (43) | 75 (30) | 96 (38) | 0.008 |
| Former | 428 (57) | 124 (49) | 158 (63) | 146 (58) | |
| Current | 49 (6) | 20 (8) | 19 (7) | 10 (4) | |
| Hypertension History, n (%) | 360 (48) | 103 (41) | 121 (48) | 136 (54) | 0.01 |
| Diabetes History, n (%) | 210 (28) | 48 (19) | 86 (34) | 76 (30) | <0.001 |
| Mean creatinine, mg/dL (s.d.) | 1.3 (0.7) | 1.1 (0.3) | 1.2 (0.5) | 1.5 (1.0) | <0.001 |
| Mean body mass Index, kg/m2 (s.d.) | 29 (6) | 30 (7) | 30 (7) | 28 (7) | 0.34 |
| Mean SBP, mmHg (s.d.) | 113 (19) | 116 (16) | 115 (17) | 109 (21) | <0.001 |
| Cardiomyopathy Etiology Ischemic, n (%) | 250 (33) | 31 (12) | 102 (40) | 117 (46) | <0.001 |
| Heart Failure Type Diastolic, n (%) | 94 (12) | 47 (50) | 25 (27) | 22 (23) | 0.01 |
| NYHA | |||||
| I, n (%) | 115 (15) | 77 (31) | 31 (12) | 7 (3) | <0.001 |
| II | 330 (44) | 129 (51) | 115 (46) | 86 (34) | |
| III | 222 (29) | 41 (16) | 82 (33) | 99 (39) | |
| IV | 89 (12) | 5 (2) | 24 (9) | 60 (24) | |
| EF, mean (s.d.) | 32 (16) | 41 (14) | 30 (15) | 24 (16) | <0.001 |
| Cardiac Resynchronization, n (%) | 208 (28) | 38 (15) | 74 (29) | 96 (38) | <0.001 |
| Ace-inhibitor or ARB, n (%) | 648 (86) | 227 (90) | 225 (89) | 196 (78) | 0.001 |
| Beta blocker, n (%) | 626 (83) | 210 (83) | 214 (85) | 202 (80) | 0.35 |
| Mean BNP32, pg/ml (s.d.) | 327 (509) | 33 (47) | 154 (106) | 794 (657) | <0.001 |
*
ANOVA for continuous variables; Chi-square test for categorical