Table 3. Significances on interactions (Pr > |t|) between time and treatment with the mixed-effect model.

Effect	Groups	urinary FB1	Urinary Sa/So	Serum Sa/So
Intercept		<0.0001	<0.0001	<0.0001
Groups	placebo	–	–	–
Groups	500mg	0.8587	0.9010	0.8137
Groups	1000mg	0.7939	0.5078	0.8073
Time		0.8306	0.9494	0.6992
Time * Groups	placebo	–	–	–
Time * Groups	500mg	0.0027	0.0387	0.3785
Time * Groups	1000mg	0.0006	0.0204	0.8576