Skip to main content
. 2015 Dec 2;5:17420. doi: 10.1038/srep17420

Figure 6. Model of PEX26 targeting.

Figure 6

TA proteins are translated in the cytosol and require chaperone systems for post-translational targeting. The peroxisomal TA protein PEX26 is recognized by Get3 in the cytosol and directed to the ER. The receptor complex consisting of Get1 and Get2 mediates the insertion of PEX26 into the ER membrane. In the membrane, PEX26 is sorted into pre-peroxisomal vesicles that require Pex19 for budding from the ER. In the absence of GET3, the majority of cytosolic PEX26 is stabilized by the PMP chaperone Pex19 and directly targeted to the peroxisome, where an interaction of Pex19 and Pex3 mediates the integration of PEX26 into the peroxisomal membrane. If both, Get3 and Pex19, are inactivated, PEX26 is degraded by the proteasome.