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. 2015 Dec 2;5:17536. doi: 10.1038/srep17536

Table 2. Endogenous metabolites of the serum from CP-induced rats and their identification results (mean ± SD, n = 6).

No. TR(min) Molecular ion Measured mass (Da) VIP Formula Metabolites Relative Intensity HMDB KEGG
BK CP CP+G
M1 9.25 [M+H]+ 524.3712 26.43 C26H54NO7P LysoPC (18:0) 98.53 ± 6.81 145.51 ± 8.73** 107.49 ± 5.78# 10384 C04230
M2 7.50 [M+H]+ 274.2743 7.39 C11H23N5O3 Valylarginine 18.47 ± 4.89 24.67 ± 5.79* 20.49 ± 4.31 29121 –
M3 7.59 [M+H]+ 544.3393 10.49 C28H50NO7P LysoPC (20:4) 247.83 ± 10.44 337.47 ± 14.73** 269.84 ± 12.83## 10395 C04230
M4 9.25 [M+H]+ 546.3525 12.46 C28H52NO7P LysoPC (20:3) 231.74 ± 9.83 296.58 ± 12.81* 287.37 ± 10.99 10394 C04230
M5 4.67 [M+H]+ 400.3403 2.16 C23H45NO4 L-Palmitoylcarnitine 49.39 ± 4.28 87.33 ± 8.83** 52.17 ± 6.68# 00222 C02990
M6 5.11 [M+H]+ 347.2217 3.22 C21H30O4 Cortexolone 24.36 ± 5.47 46.32 ± 8.99** 41.36 ± 6.84 00015 C05488
M7 5.64 [M+H]+ 372.3108 4.17 C21H41NO4 Myristoylcarnitine 10.35 ± 3.28 17.93 ± 4.12* 15.49 ± 4.08 05066 –
M8 6.39 [M+H]+ 426.3578 3.98 C25H47NO4 Oleoylcarnitine 37.72 ± 7.76 55.74 ± 8.58* 35.37 ± 5.76## 05065 –
M9 6.80 [M+H]+ 468.3088 5.65 C22H46NO7P Lyso PC (14:0) 184.38 ± 13.36 222.73 ± 17.41* 204.28 ± 12.84 10379 C04230
M10 7.75 [M+H]+ 262.1160 4.59 C11H19NO6 Succinylcarnitine 9.76 ± 1.35 17.82 ± 2.32* 10.73 ± 2.21# 61717 –
M11 6.25 [M+H]+ 318.3035 3.57 C18H39NO3 Phytosphingosine 14.86 ± 2.35 29.65 ± 3.44** 19.76 ± 3.32# 04610 C12144
M12 7.39 [M+H]+ 520.3399 20.34 C26H50NO7P LysoPC (18:2) 204.93 ± 18.48 154.32 ± 9.38** 229.39 ± 14.57## 10386 C04230
M13 7.82 [M+H]+ 496.3398 9.465 C24H50NO7P LysoPC (16:0) 358.39 ± 15.18 312.43 ± 12.19* 316.48 ± 14.74 10382 C00157
M14 9.74 [M+H]+ 550.3869 14.58 C28H56NO7P LysoPC (20:1) 198.42 ± 9.87 147.35 ± 8.47* 154.91 ± 9.15 10391 C04230
M15 8.42 [M+H]+ 522.3553 11.49 C26H52NO7P LysoPC (18:1(11Z)) 152.88 ± 8.76 113.36 ± 7.90* 142.37 ± 10.27# 10385 C04230
M16 1.98 [M+H]+ 249.0615 4.78 C9H15N2O6 γ-glutamylthreonine 34.43 ± 4.62 26.67 ± 5.32* 45.32 ± 5.44## 00713 –
M17 2.15 [M+H]+ 251.0696 4.39 C8H14N2O5S γ-glutamylcysteine 21.43 ± 3.25 15.38 ± 2.36* 19.48 ± 2.41# 01049 C00669
M18 4.20 [M-H]− 391.2847 8.94 C24H40O4 Chenodesoxycholic acid 4.78 ± 0.43 10.98 ± 1.03** 4.69 ± 0.76# 00951 C05465
M19 3.82 [M-H]− 391.2841 4.32 C24H40O4 Deoxycholic acid 18.47 ± 6.87 31.75 ± 7.86** 20.86 ± 8.86# 11637 C05122
M20 3.75 [M-H]− 514.2834 17.70 C26H45NO7S Tauroursocholic acid 21.37 ± 4.90 12.47 ± 4.01** 19.35 ± 5.78# 00889 –
M21 1.90 [M-H]− 212.0029 12.67 C8H7NO4S Indoxyl sulfate 13.25 ± 3.25 27.33 ± 5.24** 17.79 ± 4.38# 03309 –
M22 8.33 [M-H]− 283.2646 4.41 C18H36O2 Stearic acid 89.24 ± 6.96 149.75 ± 14.38** 107.84 ± 12.47# 00827 C01530
M23 3.12 [M-H]− 445.1892 6.33 C24H30O8 Estrone 3-glucuronide 14.23 ± 4.39 23.46 ± 5.49** 17.85 ± 5.77# 04483 C11133
M24 4.92 [M-H]− 329.2330 3.47 C22H34O2 Docosapentaenoic acid 12.93 ± 3.31 27.37 ± 3.38** 28.84 ± 6.49 06528 C16513
M25 3.88 [M-H]− 512.2680 10.25 C26H43NO7S Glycolithocholate sulfate 9.73 ± 3.18 28.64 ± 6.42** 22.87 ± 6.43 02639 C11301
M26 6.07 [M-H]− 389.2687 4.68 C24H38O4 7a-Hydroxy-3-oxo-5β- cholanoic acid 3.58 ± 0.67 5.48 ± 0.89* 4.46 ± 0.87 00503 C00281
M27 5.39 [M-H]− 407.2797 4.60 C24H40O5 Cholic acid 5.63 ±1.01 8.64 ± 0.82* 7.52 ± 1.56 02639 C11301
M28 6.71 [M-H]− 429.3010 3.52 C27H42O4 7a-Hydroxy-3-oxo-4- cholestenoate 6.87 ± 0.95 9.32 ± 0.99* 7.10 ± 1.02# 12458 C00157
M29 3.88 [M-H]− 512.2676 5.42 C26H43NO7S Sulfolithocholylglycine 46.25 ± 6.42 24.17 ± 4.32** 32.29 ± 4.48# 00619 C00695
M30 2.02 [M-H]− 203.0836 2.98 C11H12N2O2 Tryptophan 16.48 ± 3.11 9.78 ± 1.07* 10.74 ± 1.21# 00929 C00525
M31 4.82 [M-H]− 464.3012 23.83 C26H43NO6 Glycocholic acid 31.03 ± 5.11 24.56 ± 6.47* 29.47 ± 8.79 00138 C01921
M32 8.62 [M-H]− 566.3456 23.93 C30H50NO7P LysoPC (22:6) 197.33 ± 12.54 135.83 ± 11.25* 147.78 ± 10.83 10404 C04230
M33 4.43 [M-H]− 188.0724 4.44 C11H11NO2 3-Indolepropionic acid 12.44 ± 1.24 8.49 ± 0.87* 10.82 ± 0.90# 02302 –

BK for blank group, CP for CP treated group and CP+G for CP and ginseng co-treated group. Compared with BK, *p < 0.05 and **p < 0.01; Compared with CP, #p < 0.05 and ##p < 0.01.