Table 1. Eighteen mitochondria-related miRNAs selected from severe asthenozoospermia.
miRNA | Fold change | Regulation | Sequence | Chr | Target gene/Target gene predicted |
---|---|---|---|---|---|
miR-151a-5p | 8.2738 | up | UCGAGGAGCUCACAGUCUAGU | Chr8 | CYTB23 |
miR-34b-5p | 2.4916 | up | UAGGCAGUGUCAUUAGCUGAUUG | Chr11 | ATP8, COX223 |
let-7b-5p | 2.0367 | down | UGAGGUAGUAGGUUGUGUGGUU | Chr22 | ATP6, ATP8, COX2, ND523 |
let-7c-5p | 7.8409 | down | UGAGGUAGUAGGUUGUAUGGUU | Chr21 | ATP6, ATP8, COX223 |
miR-101-3p | 2.0692 | down | UACAGUACUGUGAUAACUGAA | Chr1 | ATP5B9, Mcl-110 |
miR-21-5p | 3.7405 | down | UAGCUUAUCAGACUGAUGUUGA | Chr17 | ND123 |
miR-324-3p | 3.9598 | down | ACUGCCCCAGGUGCUGCUGG | Chr17 | ND623 |
miR-324-5p | 4.7185 | down | CGCAUCCCCUAGGGCAUUGGUGU | Chr17 | ND623 |
miR-30b-5p | 4.0156 | down | UGUAAACAUCCUACACUCAGCU | Chr8 | ND623 |
miR-34a-5p | 8.8067 | down | UGGCAGUGUCUUAGCUGGUUGU | Chr1 | Txnrd232 |
miR-454-3p | 8.3649 | down | UAGUGCAAUAUUGCUUAUAGGGU | Chr17 | COX123 |
miR-15a-5p | 2.4588 | down | UAGCAGCACAUAAUGGUUUGUG | Chr13 | UCP-240, Bcl-241 |
miR-15b-5p | 3.3560 | down | UAGCAGCACAUCAUGGUUUACA | Chr3 | Arl212, Bcl-242 |
miR-16-5p | 2.1482 | down | UAGCAGCACGUAAAUAUUGGCG | Chr13/Chr3 | Bcl-242 |
miR-183-5p | 2.6555 | down | UAUGGCACUGGUAGAAUUCACU | Chr7 | IDH211 |
miR-210-3p | 2.6801 | down | CUGUGCGUGUGACAGCGGCUGA | Chr11 | SDHD16, COX1013 |
miR-222-3p | 4.2907 | down | AGCUACAUCUGGCUACUGGGU | ChrX | PUMA30 |
miR-335-5p | 3.5042 | down | UCAAGAGCAAUAACGAAAAAUGU | Chr7 | SOD232 |