Table 1.

Mean Plasma Glucose, Insulin, and Intact Proinsulin Concentrations During the Oral Glucose Challenge Tests.

Parameter	Healthy subjects	Impaired glucose tolerance	Type 2 diabetes
N	10	10	10
Glucose (mg/dL)
0 hours	94 ± 8a,b	102 ± 9b	121 ± 20
1 hour	140 ± 29b	168 ± 57b	230 ± 51
2 hours	90 ± 24a,b	150 ± 34b	213 ± 34
Insulin (µU/mL)
0 hours	7.2 ± 3.5a,b	12.4 ± 5.5b	18.8 ± 10.2
1 hour	45.3 ± 33.5a	106.8 ± 31.6b	66.4 ± 29.6
2 hours	24.0 ± 17.6a,b	113.6 ± 114.7	53.3 ± 12.4
Intact proinsulin (pmol/L)
0 h	3.1 ± 1.9a	6.1 ± 4.1	7.3 ± 7.0
1 h	10.3 ± 6.8a,b	22.6 ± 8.1	25.5 ± 8.8
2 h	10.2 ± 5.2a,b	27.8 ± 5.9	26.7 ± 10.1

^aP < .05 vs IGT group. ^bP < .05 vs T2D group.