Figure 3.

The Impact of Cultrex coating on continuous glucose monitoring (CGM) in vivo. To determine the impact of Cultrex coatings on sensor function we utilized our murine model of CGM.³⁷ For these studies Cultrex coated Abbott sensors were compared with uncoated Abbott sensor implanted subcutaneously in mice over a 4-week time period. The resulting sensor output (nA) and actual blood glucose levels were evaluated using standard MARD analysis using Mann–Whitney U tests and Student t tests. Cultrex coated sensors preformed significantly better then uncoated sensors over the entire 4-week time period (total mean MARD P = .0114). Cultrex coated sensor performed statistically better then uncoated sensors at 2 weeks (P = .0058) and 3 weeks (P = .0303) post–sensor implantation. Although sensor performance was better in the Cultrex coated sensor at week 4, it was not statistically significant (P = .1774).