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. 2015 Dec 2;12:52. doi: 10.1186/s12986-015-0047-9

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© Veleba et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Metabolic flexibility after the interventions. RQ data from indirect calorimetry at week 24 (see Table 3) were used to construct PRCF curves, each of which represents data (~400) pooled from all patients in the given subgroup either in fasting state (dashed lines) or during clamp (solid lines). RQ values corresponding to EC₅₀ (50^th percentile value) on each of the curves were obtained and the difference between this RQ value assessed during the clamp and fasting, respectively, was used as a marker of metabolic flexibility to glucose (PRCF curve shift; Placebo, 0.04; Pio, 0.06; Omega-3, 0.06; Pio& Omega-3, 0.07)