Table 4.
Multiple drug resistant strains recovered from blood cultures of cancer patients
| Microorganism | Multiple drug resistant isolates (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Total | Period 1 | Period 2 | |||||||
| Number | CTX-R | CTX-S | p value | Number | CTX-R | CTX-S | p value | ||
| Gram negatives (n = 49) | a34/49 (69.3) | a15/25a (60.0) | 9/15 | 6/15 | 0.273 | a19/24a (79.2) | 16/19 | 3/19 | <0.001 |
| Enterobacteriaceae (n = 32) | 28/32 (87.5) | 12/16a (75.0) | 7/12 | 5/12 | 0.414 | 16/16b (100.0) | 13/16 | 3/16 | <0.001 |
| Escherichia coli (n = 8) | 8/8 (100) | 5/5a (100) | 3/5 | 2/5 | 0.527 | 3/3a (100) | 1/3 | 2/3 | 0.414 |
| K. pneumoniae (n = 3) | 3/3 (100) | 0 | 0 | 0 | – | 3/3 (100) | 3/3 | 0/3 | 0.014 |
| Citrobacter species (n = 12) | 9/12 (75.0) | 5/8a (62.5) | 3/5 | 2/5 | 0.527 | 4/4a (100) | 4/4 | 0/4 | 0.004 |
| Enterobacter species (n = 7) | 7/7 (100) | 1/1a (100) | 1/1 | 0/1 | – | 5/6a (100) | 5/6 | 0/6 | <0.001 |
| Providencia species (n = 1) | 0/1 (0.0) | 0/1 | 0 | 0 | – | 0 | 0 | 0 | – |
| Salmonella typhimurium (n = 1) | 1/1 (100) | 1/1 (100) | 0/1 | 1/1 | – | 0 | 0 | 0 | – |
| Acinetobacter species (n = 7) | 6/7 (85.7) | 3/3a (100) | 2/3 | 1/3 | 0.414 | 3/4a (75) | 3/4 | 0/4 | 0.028 |
| Pseudomonas aeruginosa (n = 10) | 0/10 (0.0) | 0/6a (0.0) | – | – | 0/4a (0.0) | – | – | ||
| Gram positives (n = 40) | b6/40 (15.0) | b1/22a (4.5) | – | – | b5/18b | – | – | ||
| Enterococcus species (n = 2) | 1/2 (50.0) | 1/1a (50.0) | – | – | 0/1a (0.0) | – | – | ||
| Staphylococcus aureus (n = 4) | 1/4 (25.0) | 0/3a (0.0) | – | – | 1/1a (100) | – | – | ||
| Staphylococcus epidermidis (n = 28) | 2/28 (7.2) | 0/16a (0.0) | – | – | 2/12a (16.7) | – | – | ||
| Streptococcus species (n = 6) | 2/6 (33.3) | 1/2a (50.0) | – | – | 1/4a (25.0) | – | – | ||
| Total | 39/89 (43.9) | 16/47a (34.1) | 23/42b (54.7) | ||||||
Numbers with differing superscripts within antimicrobial agent are significantly different at the p < 0.05
CTX-R cefotaxime (30 μg) resistant, CTX-S cefotaxime susceptible, Period 1 first study period, Period 2 second study period