Table 3.
Demographic characteristics of the whole group of 60 patients based on the exacerbation frequency
| <1Exacerbation/year n = 11 | 1-2 Exacerbations/year n = 31 | >2 Exacerbations/year n = 18 | Between-group p value | |
|---|---|---|---|---|
| Male/Female | 7/4 | 19/12 | 9/9 | 0.68 |
| Age, yr | 32.5 ± 11.9 | 34.2 ± 10.2 | 33 ± 9.7 | 0.86 |
| BMI, Kg/ m2 | 23.3 ± 3.4 | 22.6 ± 2.8 | 23.9 ± 3.1 | 0.33 |
| 508 del homozygous/heterozygous | 0/10 | 8/16 | 6/7 | 0.001 |
| Pancreatic insufficiency, n (%) | 3 (27.2) | 22 (70.9) | 15 (83.3) | 0.006 |
| CF-related diabetes, n (%) | 1 (9.1) | 4 (12.9) | 9 (50) | 0.006 |
| Lung function | ||||
| FEV1,L | 3.09 ± 0.77 | 2.6 ± 0.73 | 2.25 ± 0.75 | 0.01 |
| FEV1, % predicted | 85 ± 22 | 72.5 ± 16 | 66.9 ± 21.8 | 0.05 |
| FVC, L | 4.2 ± 1.1 | 3.8 ± 0.97 | 3.4 ± 0.9 | 0.14 |
| FVC, %predicted | 97.3 ± 21.7 | 89.8 ± 16.2 | 86.5 ± 19.7 | 0.31 |
| Chronic infections, n (%) | ||||
| Pseudomonas aeruginosa | 3 (27.2) | 21 (67.7) | 15 (83.3) | 0.008 |
| Staphylococcus aureus | 9 (81.8) | 24 (77.4) | 9 (50) | 0.1 |
| Burkholderia cepacia | 0 (0) | 1 (3.2) | 1 (5.5) | 1 |
| Daily physical activity | ||||
| Total energy expenditure, kcal | 2701.3 ± 706.7 | 2793.2 ± 631.9 | 2570.6 ± 428.4 | 0.45 |
| Active energy expenditure, kcal | 638 (349–699) | 1003 (550–1377) | 606.5 (464–752) | 0.03 |
| Steps, number/day | 9449 ± 4981 | 10394 ± 3923 | 8018 ± 2492 | 0.11 |
| Duration physical activity, min/day | 142 (80–225) | 262 (159–327) | 135.5 (85–182) | 0.01 |
| Average METs | 1.6 (1.5–1.9) | 1.8 (1.6–2.1) | 1.6 (1.5–1.8) | 0.01 |
| Mild intensity activities, min/day | 126 (72–219) | 213 (127–310) | 119.5 (81–167) | 0.01 |
| Moderate intensity activities, min/day | 9 (5–21) | 19 (9–38) | 14.5 (6–26) | 0.3 |
| Vigorous intensity activities, min/day | 1 (0–2) | 0 (0–4) | 1 (0–2) | 0.88 |
Data are presented as mean ± SD or median and interquartile range, unless otherwise stated