Table 1.

Determination of cell concentrations and dsRNA yields obtained from a single co-cultivation of RNase-deficient E. coli

Production scale	Type of process	Medium	Cell density (×109 CFU/mLa)	dsRNAyield (μg/mLa)	Incubation time (hr.)
Laboratory	-	LB	2.4 ± 0.2	2.6 ± 0.8	8
	-	TB	4.5 ± 0.1	6.2 ± 0.2	8
Large	Batch	TB	21.1 ± 2.9	3.4 ± 0.5	8
	Fed-batch	TB	36.2 ± 4.5	95.0 ± 21.5	30

^a1 mL of bacteria culture