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. 2015 Dec 2;16:256. doi: 10.1186/s13059-015-0815-x

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© Duclot and Kabbaj. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Egr1 binds to synapse-related genes in a sex-specific and estrus cycle-specific manner. a The majority of differential Egr1 binding was observed in proestrus when compared to either males (pink circle) or diestrus females (green circle). b, c treemap representation of Cellular Compartment terms from the Gene Ontology database, showing a marked enrichment of receptors complexes, synapse, and zones of cell–cell communication localizations in proestrus when compared to males (b) or diestrus (c). The size of each rectangle is proportional to the -log10 of the p-value (the bigger the rectangle, the more significant the enrichment). d–f The enrichment analysis of pathways from the Kyoto Encyclopedia of Genes and Genomes on the nearest genes to a differential Egr1 binding locations reveals an alteration of signal transduction pathways between males and females in proestrus (d) and diestrus (e), as well as within females (f)