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. 2015 Jun 22;77(11):1419–1425. doi: 10.1292/jvms.14-0617

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©2015 The Japanese Society of Veterinary Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

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Fig. 7. — Hypothesis concerning cystic follicle (CF) formation in the pig. Ovarian development and ovulation are mainly regulated by gonadotrophins via an endocrine pathway. Firstly, FSH stimulates expression of inhibin α and betaglycan in granulosa cells in the ovary, which increases the synthesis of estrogen through upregulation of 3β-HSD. Estrogen leads to LH-induced ovulation through increased expression of LH receptor (A). However, if synthesis of FSH is insufficient in the pituitary, ovulation could fail, and cystic follicles could form due to decreased expression of inhibin α and betaglycan (B).