Table I.
Formulation processing conditions.
| Formulation | Polymer | carbamazepine % (w/w) |
Polymer %(w/w) |
Vent port |
Torque% | Pressure (Bar) |
Moisture Content % |
Drug Content % |
Screw speed (rpm) |
Temperature (°C) |
|---|---|---|---|---|---|---|---|---|---|---|
| A0 | Kollidon® 17 PF | 25 | 75 | None | 19.89 (7.48) | 2.35 (2.31) | 6.21 (1.28) | 91.79 (6.84) | 100 | 145 |
| A1 | Kollidon® 17 PF | 25 | 75 | Zone 4 | 25.52 (6.02) | 2.47 (0.03) | 2.48 (0.74) | 94.84 (4.99) | 100 | 145 |
| A2 | Kollidon® 17 PF | 25 | 75 | Zone 6 | 23.91 (2.69) | 2.52 (0.00) | 1.02 (0.84) | 99.38 (3.65) | 100 | 145 |
| A3 | Kollidon® 17 PF | 25 | 75 | Zone 9 | 20.40 (1.38) | 2.01 (0.00) | 0.73 (0.21) | 102.72 (2.47) | 100 | 145 |
| A-PM | Kollidon®17 PF | 25 | 75 | NA | NA | NA | 7.64 (0.92) | 101.31 (2.61) | NA | NA |
| D0 | Klucel™ ELF | 25 | 75 | None | 46.61 (4.22) | 2 (0) | 3.32 (2.4) | 91.41 (1.9) | 100 | 140 |
| D1 | Klucel™ ELF | 25 | 75 | Zone 4 | 73.59 (2.30) | 2 (0) | 2.71 (2.08) | 93.14 (1.51) | 100 | 140 |
| D2 | Klucel™ ELF | 25 | 75 | Zone 6 | 73.76 (1.67) | 2 (0) | 2.34 (1.29) | 95.41 (1.44) | 100 | 140 |
| D3 | Klucel™ ELF | 25 | 75 | Zone 9 | 55.95 (1.56) | 2 (0) | 1.8 (0.89) | 99.05 (1.12) | 100 | 140 |
| D-PM | Klucel™ ELF | 25 | 75 | NA | NA | NA | 3.45 (0.77) | 99.64 (1.72) | NA | NA |
Parentheses represent relative standard deviation, PM- physical mixture.