Table 1. Airway Proteins Whose Relative Levels Are Most Affected by Exposure to GSH–MDI Based on iTRAQ Analysis.

avg Δ	protein ID	protein name	MW	% coverage	scoreb	p valueb	114/116 ratio	114/116 Nb	115/117 ratio	115/117 Nb
13.23	CLCA1	Ca2+ activated chloride channel regulator 1 (aka gob-5)	107 580	55.4	6544	0	11.6940	102	14.771	152
12.84	CHIL3	Chitinase-like protein 3 (aka YM-1)	48 663	60.1	10 517	0	19.5440	262	6.131	251
11.08	CHIL4	Chitinase-like protein 4 (aka YM-2)	49 035	59.5	3131	0	16.7220	58	5.437	69
9.98	RETNA	Resistin-like alpha (aka RELMα or Fizz-1)	13 477	20.7	204	7.30 × 10−17	6.6150	2	13.335	3
9.06	MD1L1a	Mitotic spindle assembly checkpoint protein MAD1	91 094	32.8	28	0.038	13.6520	2	4.467	2
4.72	RGS9a	Regulator of G-protein signaling 9	85 137	17.6	58	0.024	7.7440	9	1.704	9
3.75	RES3G	Regenerating islet-derived protein 3-gamma	21 134	55.2	427	3.50 × 10−39	4.2240	12	3.271	11
3.33	C1QBa	Complement C1q subcomponent subunit B	29 234	19	35	0.024	3.6650	2	3.004	2
3.16	CHAD	Chondroadherin	44 295	28.5	160	1.80 × 10−12	4.3380	3	1.986	3
2.69	PIGR	Polymeric immunoglobulin receptor	92 309	29.7	1737	0	3.2070	37	2.176	40
2.57	CATS	Cathepsin S	42 736	25.3	335	5.40 × 10−30	2.7010	11	2.441	10
2.49	HA10	H-2 class I histocompatibility antigen, Q10 alpha chain	38 896	11.7	99	0.0000019	2.5160	3	2.458	3
2.24	PSME2	Proteasome activator complex subunit 2	30 583	45.2	146	4.10 × 10−11	1.9150	2	2.563	3
2.21	VCAM1	vascular cell adhesion protein 1	89 611	20.8	81	0.00012	2.5420	3	1.878	3
2.14	PAFA	Platelet-activating factor acetylhydrolase	53 748	14.3	79	0.00021	2.3640	3	1.925	4
2.01	IGHA	IgA constant region	39 611	23.3	756	4.30 × 10−72	2.1810	18	1.838	11
0.52	ADIPO	Adiponectin	28 924	27.5	367	3.10 × 10−33	0.5840	12	0.448	13
0.50	TMPSDa	Transmembrane protease serine 13	64 166	16.8	37	0.004	0.5340	3	0.466	3
0.48	FLNB	Filamin-B	305 321	13.5	31	0.018	0.5310	2	0.431	2
0.47	BPIA1	BPI fold-containing family A member 1 (aka PLUNC)	30 363	61.5	1045	5.40 × 10−101	0.5150	31	0.428	32
0.44	CBPM	Carboxypeptidase M	54 669	17.6	75	0.00058	0.5010	2	0.383	2
0.44	NAPSAa	Napsin-A	47 788	2.1	75	0.00051	0.4720	4	0.4	4
0.43	MAL2a	Protein MAL2	19 598	6.3	26	0.06	0.5740	2	0.29	2
0.42	XRCC1	DNA repair protein XRCC1	75 323	8.4	53	0.091	0.3110	3	0.521	2
0.29	INMT	Indolethylamine N-methyltransferase	32 662	23.9	132	1.20 × 10−09	0.3450	3	0.238	3

^aOnly 1 unique peptide with significant identity.

^bScore and p value are based on Mascot Probability; N = number of peptides from which experimental ratios are calculated.