Skip to main content
. Author manuscript; available in PMC: 2016 Jul 23.
Published in final edited form as: J Med Chem. 2015 Jul 9;58(14):5459–5475. doi: 10.1021/acs.jmedchem.5b00391

Scheme 1. a. Synthesis of prodrugs 2 and 3.

Scheme 1

aReaction conditions: (a) N-hydroxysuccinimidyl 2-benzyloxybenzoate, Cs2CO3, DMF, 0 °C to rt, 21 h, 62%; (b) 80% aqueous TFA, 0 °C to rt, 4 h; (c) Ac2O, pyridine, DMF, rt, 16 h, 63% (2 steps); (d) H2, Pd/C, MeOH, rt, 2 h, 42%; (e) Ac2O, pyridine, DMF, rt, 20 h, 46%.