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. Author manuscript; available in PMC: 2016 Jul 23.
Published in final edited form as: J Med Chem. 2015 Jul 9;58(14):5459–5475. doi: 10.1021/acs.jmedchem.5b00391

Table 3.

Caco-2 permeability studies of select compounds.

Compound Papp, A to B
10−6 cm/s		 Papp, B to A
10−6 cm/s		 efflux ratio
1 1.23 0.96 0.78
2 0.62 0.97 1.55
4 1.23 0.86 0.69
7 0.52 1.8 3.45
8 4.20 1.34 0.32