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. 2015 Dec 9;31(1):8–19. doi: 10.1097/YIC.0000000000000105

Fig. 2.

Fig. 2

Adjusted mean change from baseline at each visit in (a) HAM-D17 total score and (b) sleep disturbance symptoms measured by HAM-D (full analysis set, MMRM). HAM-D, Hamilton Rating Scale for Depression; MMRM, mixed-effect model for repeated measures. *P<0.05 for fixed dose versus placebo group.