Comparison of the receiver operating characteristic (ROC) curves for the septic acute kidney injury (SAKI) risk model, Pediatric Risk of Mortality (PRISM), and Pediatric Sepsis Biomarker Risk Model (PERSEVERE), for estimating the risk of SAKI on day 3 of septic shock (combined derivation and test cohorts, n = 441). The ROC curve for the SAKI risk model (solid black line) yielded an area under the curve of 0.90 (CI95, 0.85–0.96), which was superior to that of PRISM (solid gray line; 0.73; CI95, 0.66–0.82; p < 0.001) and PERSEVERE (dashed black line; 0.66; CI95, 0.55–0.76; p < 0.0001) for estimating the risk of SAKI on day 3 of septic shock.