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. Author manuscript; available in PMC: 2015 Dec 2.
Published in final edited form as: Bioorg Med Chem. 2014 Jan 23;22(5):1726–1735. doi: 10.1016/j.bmc.2014.01.017

Scheme 2.

Scheme 2

Reagents and conditions: (i) TBSCl (6.0 equiv), imidazole, DMF, 16 h, 70%; (ii) 2:1:1 H2O–THF–TFA, 2 h, 81%; (iii) NaH, H2NSO2Cl, dioxane, 24 h, 60%; (iv) 9, Cs2CO3, DMF, 24 h; (v) 4:1 TFA–H2O, 20 °C, 60 h, 3% from 14.