Table 1.
Human CYP4 Enzymes: Tissue Distribution and Fatty Acid ω-Hydroxylase Activities
| Enzyme | Tissue Distribution | Substrates |
|---|---|---|
| CYP4A11 | Liver, kidney | AA, ω3 PUFA, MCFA, LCFA |
| CYP4A22 | Liver, kidney | ? |
| CYP4B1 | Lung, bladder | Inactive in human, SCFA in other species |
| CYP4F2 | Liver, kidney | LTB4, AA, MCFA, LCFA, VLCFA, LX, EET, HETE |
| CYP4F3A | Myeloid tissues | LTB4, ω3 PUFA, MCFA, LCFA, LX, EET, HETE |
| CYP4F3B | Liver, kidney | AA, ω3 PUFA, MCFA, LCFA, VLCFA, LTB4, EET |
| CYP4F8 | Urogenital tissues | PGH1/2 (internal oxidations) |
| CYP4F11 | Liver, kidney | MCFA, LCFA (3-hydroxy analogs), AA, LTB4, LX, HETE |
| CYP4F12 | Liver, gut, kidney | AA, PGH1/2 (internal oxidations) |
| CYP4F22 | Skin | Hepoxilins?, acylceramides? |
| CYP4V2 | Retina | ω3 PUFA, AA, MCFA |
| CYP4X1 | Brain, bronchial airways | No reported ω-hydroxylase activity |
| CYP4Z1 | Mammary tissue | MCFA (internal oxidations), AA? |
AA, arachidonic acid; LTB4, leukotriene B4; PGH1/2, prostaglandin H1/2; SCFA (C7–C9), short-chain fatty acid; MCFA (C10–C16), medium chain fatty acid; LCFA (C17–C21), long-chain fatty acid; VLCFA (C22–C26), very long-chain fatty acid; ω3 PUFA, omega 3 polyunsaturated fatty acid; LX, lipoxin; HETE, hydroxyeicosatrienoic acid; EET, epoxyeicosatrienoic acid.
Information taken from references throughout the text.