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. Author manuscript; available in PMC: 2016 Sep 24.
Published in final edited form as: J Med Chem. 2015 Sep 3;58(18):7349–7369. doi: 10.1021/acs.jmedchem.5b00719

Figure 3.

Figure 3

(A) Representative examples of biotin-AMP nucleoside-based bisubstrate inhibitors of BPL including: alkylphosphate 10, β-ketophosphonate 11, 1,2,3 triazole 12, acylsulfamate 13, acylsulfamide 14, acylsulfonamide 15, 3-deaza acylsulfamate 16, and 2-tert-butylethynyl-acylsulfamate 17. (B) Benzoxazoline moiety 18, a selective inhibitor of S. aureus BPL. (C) Biotin based inhibitors 19 and 20 of S. aureus BPL.