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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 Jun 20;85:262–272. doi: 10.1016/j.yjmcc.2015.06.011

FIGURE 3. Effect of OM on myofilament Ca2+ sensitivity (pCa50).

FIGURE 3

Force-pCa relationships were constructed by plotting normalized forces generated against a range of pCa. (A) Effect of OM on the force-pCa relationships in WT preparations. (B) Effect of OM on the force-pCa relationships in KO preparations. (C) Effect of OM on the force-pCa relationships in donor human heart preparations. Treatment with OM caused a significant left-ward shift in the force-pCa relationships in all the three groups indicating that OM caused a significant increase in pCa50. 14–15 preparations from 5 hearts were analyzed for WT and WT+OM groups. 15 preparations from 5 hearts were analyzed for KO and KO+OM groups. 14 preparations from 3 hearts and 13 preparations from 3 hearts were analyzed for human and human+OM groups, respectively with multiple preparations from each heart.