Skip to main content
. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 Jun 20;85:262–272. doi: 10.1016/j.yjmcc.2015.06.011

FIGURE 5. Effect of OM on the rate of force redevelopment (ktr).

FIGURE 5

The effects of OM on ktr were assessed both at equivalent pCa (pCa 6.1) (A) and at equivalent levels of activation (see Table 2 for pCa values) (B) in WT and KO groups, using a mechanical slack-restretch maneuver [35], before (white bars) and following (grey bars) incubation with OM. As reported earlier [53], KO preparations exhibited a significant acceleration of ktr when compared to the WT preparations prior to incubation with OM. Similar trend persisted even after incubation with OM. Values are expressed as mean ± S.E.M. Independent t-tests were used to compare the data between WT and KO groups and paired t-tests were used to compare the data between pre- and post-OM treatment with in the same group. 14 preparations were analyzed from 5 WT hearts and 18 preparations from 7 KO hearts, with multiple preparations from each heart. * P < 0.05.