. Author manuscript; available in PMC: 2016 Aug 1.

Published in final edited form as: J Mol Cell Cardiol. 2015 Jun 20;85:262–272. doi: 10.1016/j.yjmcc.2015.06.011

Table 2.

Steady-state and dynamic contractile parameters measured before and following incubation with OM at similar levels of force production

Group	pCa	P1	k_tr (s⁻¹)	k_rel (s⁻¹)	k_df (s⁻¹)
Pre-OM
WT	5.98±0.02	0.561±0.015	2.90±0.28	251.24±23.92	4.54±0.30
KO	5.94±0.02	0.482±0.021^*	6.32±0.50^*	409.13±48.34^*	7.17±0.42^*
Post-OM
WT	6.14±0.02^†	0.672±0.026^†	2.08±0.23^†	99.78±9.24^†	1.58±0.19^†
KO	6.12±0.02^†	0.571±0.025^*^†	3.61±0.26^*^†	89.30±15.69^†	2.79±0.24^*^†

P1: XB stiffness; k_tr: rate of force redevelopment; k_rel: rate of XB detachment; k_df: rate of XB recruitment. Independent t-tests were used to compare the data between WT and KO groups and paired t-tests were used to compare the data between pre- and post-OM treatment with in the same group. 13–16 preparations were analyzed from 5 WT hearts, and 17–18 preparations were analyzed from 7 KO hearts, with multiple preparations from each heart. Values are expressed as mean ± S.E.M.

Significantly different from the corresponding WT within each group; P < 0.05.

^†

Significantly different from the corresponding pre-OM group; P < 0.05.