Skip to main content
. 2015 Feb 27;172(23):5661–5675. doi: 10.1111/bph.13068

Figure 3.

figure

CTS reduces MMP‐9 expression and activity. Effect of CTS on oxLDL‐stimulated MMP‐9 expression and activity in SMCs. Rat aortic SMCs were pretreated with CTS for 3 h then stimulated with oxLDL (80 μg mL−1) for 24 h. Whole cell lysates were subjected to MMP‐9 protein expression (A). The conditioned medium from each treatment group was collected and subject to gelatin zymography (B). n = 6. ### P < 0.001 compared with untreated control group; *P < 0.05, **P < 0.01 compared with oxLDL‐treated group respectively. (C) MMP‐9 immunohistochemical staining (red) of aortic sinus from ApoE −/− mice receiving CTS or vehicle treatment. SMCs were stained with α‐SMA (green) and nuclei were stained with 4',6‐diamidino‐2‐phenylindole (DAPI) (blue). Scale bar, 50 μm. n = 8 for each group.