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| Weaning | Procedures for selective breeding | Behavioral testing | |||||
|---|---|---|---|---|---|---|---|
| Age (weeks) | 3 | 4 | 5–7 | 8 | 9 | 10 | 16–24 |
| Naive rats | TF, PPI | group housing (3–4 rats/cage) | TF, PPI | HB | Telemetry recordings | ||
| New substrain | social isolation | social isolation + ketamine treatment (30 mg/kg/daily) | group housing | ||||
Abbreviations: TF: tail-flick test, PPI: prepulse inhibition test, HB: hole-board test.
