Table 4. Univariate and multivariate Cox proportional hazard analysis of risk factors for death in patients with PH-IIP.
| Univariate model HR (95% CI) | P value | Multivariate model HR (95% CI) | P value | |
|---|---|---|---|---|
| NYHA IV | 2.122 (1.288–3.496) | 0.003 | 1.626 (1.211–2.183) | 0.001 |
| Age* (years) | 1.118 (0.989–1.264) | 0.075 | ||
| 6-MWD # (m) | 0.958 (0.934–0.983) | 0.001 | ||
| SvO2 $ (%) | 0.774 (0.658–0.910) | 0.002 | 0.712 (0.577–0.880) | 0.002 |
| TLC $ (% pred.) | 0.934 (0.868–1.005) | 0.067 | 0.888 (0.819–0.963) | 0.004 |
| PaO2 (mmHg) § | 0.873 (0.755–1.008) | 0.065 | ||
| NT pro-BNP (pg/ml) & | 1.01 (1.002–1.019) | 0.016 |
Estimated hazard ratios (HR), 95% confidence intervals (CI) and p-values were calculated by Cox regression analyses. SvO2 denotes mixed venous oxygen saturation; 6MWD, 6 min walking distance; NYHA, New York Heart Association.
* per 5-years increase
# per 10m increase
$ per 5% increase
§ per 5 mmHg increase
& per 100 pg/ml increase