Fig. 5.

Imetelstat and trastuzumab combination treatment inhibits mammosphere formation and invasive potential. A) Total mammosphere counts from 12 and 90 day pretreatment HCC1569 mammosphere cultures, Average ± SD, n=3, one-way ANOVA, * p < 0.05, ** p < 0.01, *** p < 0.001 compared to untreated. B) Representative Images of Primary Mammospheres cultured from HCC1569 cells, 4X Magnification, 200 µm scale bar. C) Representative images of invaded cells in purple, 10X magnification, 60 µm scale bar. D) Invaded cells in 10 random fields per well, Average ± SD, n=3, one-way ANOVA, ** p < 0.01 compared to untreated