Imetelstat, trastuzumab, and combination treatment decrease primary tumor growth in vivo. A) Tumor volume of HCC1954 cells by caliper measurements in PBS control (thrice weekly, n=9), trastuzumab (20 mg/kg twice weekly, n=10), imetelstat (30 mg/kg, thrice weekly, n=10), and combination (trastuzumab twice weekly and imetelstat thrice weekly, n=9) treated NSG mice. Average ± SEM B) Rate of tumor growth calculated from A) is the slope of line of the average tumor volume over time for each treatment group